Rapid detection of circulating fibrocytes by flowcytometry in idiopathic pulmonary fibrosis
نویسندگان
چکیده
منابع مشابه
Role of CXCL12/CXCR4-Mediated Circulating Fibrocytes in Pulmonary Fibrosis
Pulmonary fibrosis is characterized by excessive deposition of extracellular matrix (ECM) and remodeling of the lung architecture, with clinically irreversible loss of lung function. The exact molecular and cellular mechanisms of pulmonary fibrosis are complicated. Many types of cells are involved in the pathogenic processes. The chemokine (C-X-C motif) ligand 12 (CXCL12) can attract circulatin...
متن کاملDetection of Alveolar Fibrocytes in Idiopathic Pulmonary Fibrosis and Systemic Sclerosis
BACKGROUND Fibrocytes are circulating precursors for fibroblasts. Blood fibrocytes are increased in patients with idiopathic pulmonary fibrosis (IPF). The aim of this study was to determine whether alveolar fibrocytes are detected in broncho-alveolar lavage (BAL), to identify their prognostic value, and their potential association with culture of fibroblasts from BAL. METHODS We quantified fi...
متن کاملRole of Circulating Fibrocytes in Cardiac Fibrosis
OBJECTIVE It is revealed that circulating fibrocytes are elevated in patients/animals with cardiac fibrosis, and this review aims to provide an introduction to circulating fibrocytes and their role in cardiac fibrosis. DATA SOURCES This review is based on the data from 1994 to present obtained from PubMed. The search terms were "circulating fibrocytes " and "cardiac fibrosis ". STUDY SELECT...
متن کاملFibrocytes in pulmonary fibrosis: a brief synopsis.
Fibrocytes are bone marrow-derived, circulating mesenchymal progenitor cells that play a role in several fibrotic disorders, including lung fibrosis. They are attracted to injured tissue by various chemokines. It is likely that fibrocytes play a detrimental role in tissue homeostasis and promote fibrosis, although this paradigm needs further confirmation. This would make fibrocytes a possible n...
متن کاملREPORT OF FOUR CASES OF FAMILIAL IDIOPATHIC PULMONARY FIBROSIS
A 25 year old male and his 46 year old aunt presented with shortness of breath and a dramatic response to steroids. The other two patients are sisters with more advanced disease. One of these responded partially to steroids, while the other died within 4 months of treatment. The genetic basis and pathogenesis are discussed.
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ژورنال
عنوان ژورنال: Annals of Thoracic Medicine
سال: 2015
ISSN: 1817-1737
DOI: 10.4103/1817-1737.157294